Product Source and Extraction Process
- Our Tetrahydropalmatine (THP) is a high-purity botanical alkaloid isolated from the dried tubers of Corydalis yanhusuo W.T. Wang,
- a traditional Chinese medicinal herb also known as Yan Hu Suo. Using advanced ethanol extraction followed by column chromatography
- purification and recrystallization, we isolate the active alkaloid into an off-white to pale-yellow crystalline powder standardized
- to ≥98% Tetrahydropalmatine, verified by HPLC analysis.
Active Ingredients and Technical Specifications
- The key active compound, Tetrahydropalmatine (CAS: 2934-97-6 for levo-THP; 10097-84-4 for racemic dl-THP), is an isoquinoline
- alkaloid and one of the primary bioactive constituents of Corydalis yanhusuo. It has been widely studied for its analgesic,
- sedative, and anxiolytic properties, with a long history of use in Traditional Chinese Medicine for promoting circulation and
- easing discomfort. Unlike opioid-based analgesics, THP is believed to act through dopamine receptor modulation and calcium channel
- blockade, making it a sought-after ingredient for natural calm and discomfort-support formulations. Our 98% purity ensures a
- concentrated, consistent active profile — critical for B2B manufacturers requiring precise dosing and batch-to-batch reproducibility.
Application Scenarios
- Tetrahydropalmatine is a versatile ingredient across multiple industries:
- • Dietary supplements — calm-support capsules, sleep-aid tablets, discomfort-relief gummies, and relaxation-focused powders
- • Nutraceuticals — stress-management formulations and natural mood-support blends
- • Pharmaceutical — raw material for further processing, tablet/capsule formulation, and research & development
- • Cosmetics & personal care — emerging applications in soothing topical products and sensitive-skin formulations
- • Traditional medicine — raw material for herbal extracts and compound formulations
Procurement and Partnership Information
- We supply Tetrahydropalmatine 98% in bulk with flexible packaging: 1kg aluminum foil bags (with inner PE liner), 25kg fiber drums,
- or custom sizes to meet your production needs. Lead time: 3–7 working days for stock items. Every shipment includes a Certificate
- of Analysis (COA), MSDS, TDS, and relevant certification documents. Contact our export team for a competitive quote, custom
- specification requests, or free samples for quality evaluation.
Key Specifications
Attribute |
Value |
|
Botanical Name
|
Corydalis yanhusuo W.T. Wang
|
|
Plant Part Used
|
Dried Tubers (Rhizoma Corydalis)
|
|
Active Ingredient
|
Tetrahydropalmatine (THP)
|
|
Assay
|
≥98% (HPLC)
|
|
CAS Number
|
2934-97-6 (Levo-THP) / 10097-84-4 (Racemic)
|
|
Molecular Formula
|
C₂₁H₂₅NO₄
|
|
Molecular Weight
|
355.43 g/mol
|
|
Appearance
|
Off-White to Pale-Yellow Crystalline Powder
|
|
Odor
|
Characteristic, Slight
|
|
Extraction Method
|
Ethanol Extraction + Column Chromatography
|
|
Solubility
|
Soluble in chloroform, ethanol; slightly soluble in water
|
|
Melting Point
|
142–145°C (Levo-THP)
|
|
Mesh Size
|
80–100 mesh
|
|
Loss on Drying
|
≤1.0%
|
|
Residue on Ignition
|
≤0.1%
|
|
Heavy Metals
|
≤10ppm (As ≤2, Pb ≤2, Hg ≤0.5, Cd ≤1)
|
|
Pesticide Residue
|
Meet EP / USP standard
|
|
Microbiological
|
TPC ≤1000 cfu/g; Y&M ≤100 cfu/g; E. coli Negative; Salmonella Negative
|
|
Shelf Life
|
24 months (sealed, cool & dry, away from light)
|
|
Storage Condition
|
Store in tightly sealed containers, below 25°C, protected from light and moisture |
|
MOQ
|
1kg
|
|
Packaging
|
1kg aluminum foil bag / 25kg fiber drum / Custom
|
|
Lead Time
|
3–7 working days (stock); 15–25 days (custom)
|
FAQ
Q1: What is Tetrahydropalmatine (THP)?
- Tetrahydropalmatine (THP) is a natural isoquinoline alkaloid isolated from the tubers of Corydalis yanhusuo (Yan Hu Suo), a traditional Chinese medicinal herb. It is widely studied for its analgesic, sedative, and calm-support properties.
Q2: What is the purity of your Tetrahydropalmatine?
- Our Tetrahydropalmatine is standardized to ≥98% purity, verified by HPLC analysis. We provide a Certificate of Analysis (COA) with every shipment confirming the exact assay result for each batch.
Q3: Is this levo-THP or racemic dl-THP?
- We offer both forms. Natural extraction typically yields levo-Tetrahydropalmatine (L-THP, CAS: 2934-97-6). Racemic dl-THP (CAS: 10097-84-4) is also available upon request. Please specify your requirement when ordering.
Q4: What is the minimum order quantity (MOQ)?
- Our standard MOQ is 1kg for 98% Tetrahydropalmatine. For custom specifications, private labeling, or contract manufacturing, MOQ may vary — contact our sales team for details.
Q5: Do you provide free samples?
- Yes, we offer 5–10g free samples for quality evaluation and formulation testing. Customer covers shipping cost, which can be deducted from your first bulk order.
Q6: How should Tetrahydropalmatine be stored?
- Store in tightly sealed containers, in a cool, dry place below 25°C, protected from direct light and moisture. Under proper storage conditions, shelf life is 24 months from the date of manufacture.
Q7: Can you customize specifications or provide contract manufacturing?
- Yes. We offer custom purity levels, extraction ratios, and dosage forms (powder, granules, premixes). We also provide OEM/ODM services including private labeling, custom packaging, and formulation support. Contact us to discuss your specific needs.